服務熱線
15201163601
-
詳細解析ALZET滲透泵的分類及使用優(yōu)點
發(fā)布時間： 2021-01-21 點擊次數(shù)： 2003次ALZET滲透泵控釋制劑主要由藥物、半透膜材料、滲透壓活性物質(zhì)和推動劑組成。滲透泵片是在片芯外包被一層聚合物構成的半透性衣膜，用激光在片劑衣膜層上開一個或多個適宜大小的釋藥小孔而制成。口服后，胃腸道內(nèi)的水分通過半透膜進入片芯，因滲透壓活性物質(zhì)使膜內(nèi)溶液呈高滲，膜內(nèi)外存在的滲透壓使水分繼續(xù)進入膜內(nèi)，從而使藥物溶液或混懸的藥物從小孔泵出。常用的半透膜材料為醋酸纖維素。滲透壓活性物質(zhì)起調(diào)節(jié)藥室內(nèi)滲透壓的作用，其用量與零級釋藥時間長短有關，常用氯化鈉、乳糖、果糖、葡萄糖、甘露糖等。推動劑能吸水膨脹，將藥物層的藥物推出釋藥小孔，常用高分子量聚乙二醇等。除上述組成，滲透泵片中還可以加入助懸劑、黏合劑、潤滑劑、潤濕劑等。分類：ALZET滲透泵型控釋片一般由片芯和包衣膜兩部分組成，按照結(jié)構特點，可將口服滲透泵制劑分為初級滲透泵和多室滲透泵兩類。初級滲透泵片芯中包含藥物和促滲透劑，包衣膜由高分子材料（如醋酸纖維素）組成，包裹在片芯的表面。滲透泵片置于含水的環(huán)境中時，由于包衣膜內(nèi)外存在滲透壓差，水分通過包衣膜后形成藥物的溶液或混懸液，在包衣膜內(nèi)外滲透壓差的作用下，通過膜上的釋藥孔釋放。這種釋藥方式通常適用于在水中有一定溶解度的藥物。多室滲透泵制劑的片芯為雙層片，一層含有藥物及可溶解性輔料，另一層為遇水可膨脹的促滲透聚合物。這類滲透泵多適用于難溶性藥物滲透泵制劑的制備，釋藥過程由聚合物層膨脹產(chǎn)生推動力而將藥物混懸液推出釋藥孔。優(yōu)點：1、滲透泵型控釋片以滲透壓為驅(qū)動力，以零級釋放動力學為釋藥特征，能夠在一定的時間范圍內(nèi)以恒定的釋藥速率釋放藥物，釋藥速率一般不受釋放介質(zhì)pH、攪拌速度以及胃腸蠕動、食物等因素影響，能夠在較長時間內(nèi)維持恒速釋藥，減少用藥頻率。2、體內(nèi)外相關性較好，可避免普通口服制劑造成的血藥濃度波動較大的現(xiàn)象，提高用藥的安全性和有效性。
產(chǎn)品中心
Products
-
化學試劑
Origene parkell pan-biotech PAN lexogen Lampire labtidebiotech laborator labome ABI enzolifesciences emsdiasum EtonBioscience Equitech-bio kirgen invivogen integralmolecular Instech IndoorBiotechnologies INCELL IMMUSMOL G-Biosciences IMMUNOLOGICALS idtdna IMMUNODX ILLUMINA Immunodiagnostics IBALifeSciences Hypoxyprobe Horizon Cygnus Technologies Hellobio Greiner Cell Signaling Glycobiotech Corning FST Evrogen eurofins BioFire Defense biodatacorp atlasantibodies ATCC Astartebio ArcticZymes aobious anshlabs Advanced ChemTech Advaced Cell Diagnostics AdvanDx Agar Scientific ACBR TRc polyscience Fluka Gene Bridges fortebio Biocrick Fisher bioflux biomax beckman AmericanElements MOLTOX Permagen USA Scientific Chemgenes寡核苷酸 Asuragen vmrd抗體 Thermo asusragen AmplideX toxin polyplus signagen Berry&Associates ALZET滲透泵 alzet abcr abvector SGI-DNA Goldbio Iduron Sgidna Chromsystems Coriell GE Chemgenes Matreya Streck VMRD Sigma Cerilliant Innovative Cell Technologies Diagenode Trilinkbiotech Medkoo life diagnostics Gibco Neuromab全國總代 Novus BioLegend Bethyl Toxin Technology Listlabs Seracare 寶利嘉 賽默飛 安迪生物 行業(yè)專用試劑
-
生物試劑
Biosharp Sciex Seahorse Proteintech DiaMag complementtech PeproTech hooke Nzytech Pierce pepnet pelfreez PALL ozbiosciences OXOID ORFLO ommscientific omega nanopore ncbi NexcelomBioscience Mpbio MultiSciences MyBioSource Musechem MiltenyiBiotec minerva-biolabs microspheres-nanospheres microfil microbix modiquestresearch MOBITEC mercodia merckmillipore medicago JPT kerafast Kangchen Malvern magen Kapa Macrocyclics Macherey mabtech Lucigen leica Lifespan lifesensors lifeline life-ilab Lifecore life Licor advancedchemtech Affinity Abgent Abmgood ActiveMotif Acros Acrobiosystems enzymatics epicypher Elastin elabscience Echelon eBioscience eastcoast eaglebio E&K SCIENTIFIC ekfusa duran DSHB Dharmacon DGRC Dako Cypex comptech Encorbio Jetbiofil JCRBcellbank ISOSCIENCES INVIVOCHEM iris-biotech Full Moon BioSystems GBI FormnMax Finescience Favorgen CordenPharma CIL Chromadex Clodronateliposomes Chromogenix Chiron chemservice cellvis cellutron CELLTREAT cellscript cellbiolabs cellecta cedarlane cdnisotopes carbosynth cambio calbioreagents Buchem Boston Cellron Bioworld Biowest Biotium biostatus BiosPacific Biosearch BIOplastics Biooscientific BioPAL Biomol BIOMED Biomatik bioline Biocoat Bioclone Biocision biochain華新康信 biocell Biocare BIAseparations BDpharmingen Baseclick Badrilla B2S Life Sciences Axon Medchem AXIS-SHIELD avivasysbio avidity AVES-LABS Anatrace AlphaDiagnoesticInternational Applied Genetics Laboratories Alstem Alomone AcceGen Akina AdvancedBioMatriX Adipogen Accuratechemical Academybiomed Abcam Zymo Research Addexbio ABL Abbexa Aablocks ZeptoMetrix Tocris TAKARA Spherotech Roche Nist PBL MRC Holland rd-biotech Cellgs LC-LAB Greatcell Energy Hyclone Greerlabs GlycoSyn GlycoTech EY laboratories Cayman Bioxcell Bio－Rad Agdia Abclonal amsbio auditmicro avantilipids Alsachim HTDialysis jetPRIME Carna Biosciences FItzgerald